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pentobarbital will lessen the extent or effect of etravirine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.pentobarbital will lessen the extent or result of eplerenone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Not known.pentobarbital will lessen the level or effect of fosaprepitant